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Julian Downward Selected Research

Phosphatidylinositol 3-Kinases (PI 3 Kinase)

12/2018Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.
11/2016Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.
4/2016RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression.
11/2013Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.
5/2013Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer.
1/2010Role of RAS in the regulation of PI 3-kinase.
12/2009Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.

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Julian Downward Research Topics

Disease

51Neoplasms (Cancer)
10/2021 - 08/2002
11Lung Neoplasms (Lung Cancer)
01/2021 - 05/2013
9Carcinogenesis
01/2021 - 08/2002
8Neoplasm Metastasis (Metastasis)
01/2021 - 01/2002
8Breast Neoplasms (Breast Cancer)
11/2020 - 01/2008
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 09/2003
3Melanoma (Melanoma, Malignant)
11/2020 - 01/2012
3Adenocarcinoma of Lung
10/2019 - 05/2014
3Chromosomal Instability (Chromosome Stability)
02/2012 - 04/2006
3Ovarian Neoplasms (Ovarian Cancer)
05/2009 - 06/2007
3Small Cell Lung Carcinoma (Small Cell Lung Cancer)
07/2006 - 04/2002
2Triple Negative Breast Neoplasms
11/2020 - 01/2020
2Renal Cell Carcinoma (Grawitz Tumor)
10/2018 - 08/2010
2Polyploidy
02/2012 - 06/2007
2Colorectal Neoplasms (Colorectal Cancer)
03/2011 - 04/2006
2Parkinson Disease (Parkinson's Disease)
03/2009 - 11/2007
2Neurodegenerative Diseases (Neurodegenerative Disease)
10/2008 - 11/2007
1Fibrosis (Cirrhosis)
01/2021
1Lung Diseases (Lung Disease)
01/2021
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2021
1Adenocarcinoma
01/2019
1Kidney Neoplasms (Kidney Cancer)
10/2018
1Multiple Hamartoma Syndrome (Cowden's Disease)
11/2016
1Hyperplasia
11/2016
1Multiple Myeloma
06/2015
1Cysts
02/2014
1Disease Progression
01/2014

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
01/2019 - 09/2003
9Phosphotransferases (Kinase)IBA
01/2021 - 08/2007
8Pharmaceutical PreparationsIBA
01/2021 - 01/2006
7ErbB Receptors (EGF Receptor)IBA
01/2021 - 06/2015
7Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
12/2018 - 12/2009
6Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2019 - 03/2011
6ras ProteinsIBA
04/2015 - 12/2008
5Phosphatidylinositols (Phosphatidylinositol)IBA
07/2013 - 06/2007
4Protein Isoforms (Isoforms)IBA
10/2021 - 01/2010
4Paclitaxel (Taxol)FDA LinkGeneric
02/2012 - 06/2007
4Transforming Growth Factor beta (TGF-beta)IBA
12/2007 - 01/2002
3Tyrosine Kinase InhibitorsIBA
01/2021 - 05/2013
3Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2016 - 05/2014
3Estrogen ReceptorsIBA
09/2014 - 05/2009
3Small Interfering RNA (siRNA)IBA
05/2014 - 08/2010
3Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
07/2006 - 04/2002
2Cadherins (E-Cadherin)IBA
01/2021 - 01/2019
2osimertinibIBA
01/2021 - 01/2018
2G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2020 - 05/2013
2Glutathione (Reduced Glutathione)IBA
10/2018 - 01/2016
2Carrier Proteins (Binding Protein)IBA
12/2017 - 06/2007
2Tyrosine (L-Tyrosine)FDA Link
11/2016 - 12/2011
2Proteasome Endopeptidase Complex (Proteasome)IBA
04/2015 - 08/2012
2DNA (Deoxyribonucleic Acid)IBA
01/2015 - 07/2007
2MicroRNAs (MicroRNA)IBA
01/2014 - 01/2008
2Epidermal Growth Factor (EGF)IBA
09/2012 - 06/2002
2Biomarkers (Surrogate Marker)IBA
03/2012 - 08/2010
2CeramidesIBA
02/2012 - 06/2007
2taxaneIBA
05/2009 - 04/2006
2Cytotoxins (Cytolysins)IBA
08/2007 - 06/2007
2Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
04/2007 - 05/2006
1Anti-Bacterial Agents (Antibiotics)IBA
01/2021
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
01/2021
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2021
1trovafloxacinIBA
01/2021
1Transcription Factors (Transcription Factor)IBA
01/2021
1human ERBB2 proteinIBA
11/2020
1Progesterone Receptors (Progesterone Receptor)IBA
11/2020
1Ribosomal Protein S6IBA
01/2020
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2019
1Sodium-Glucose Transporter 1IBA
01/2019
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
01/2019
1Insulin-Like PeptidesIBA
01/2019
1Codon (Codons)IBA
01/2019
1Glucose (Dextrose)FDA LinkGeneric
01/2019
1ARS-1620IBA
01/2019
1Serum Response FactorIBA
01/2019
1Fatty Acids (Saturated Fatty Acids)IBA
10/2018
1Cetuximab (Erbitux)FDA Link
01/2018
1Trastuzumab (Herceptin)FDA Link
01/2018
1Monoclonal AntibodiesIBA
01/2018
1Messenger RNA (mRNA)IBA
12/2017
1TristetraprolinIBA
12/2017
1thiamine triphosphorate (TTP)IBA
12/2017
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
11/2016
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
11/2016
1TensinsIBA
11/2016
1Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
11/2016
1AntibodiesIBA
06/2015
1Bortezomib (Velcade)FDA Link
06/2015
1olaparibIBA
04/2015
1Poly(ADP-ribose) Polymerase InhibitorsIBA
04/2015
1NucleotidesIBA
01/2015
1CateninsIBA
11/2014
1Neurofibromin 1 (Neurofibromin)IBA
05/2014
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
02/2014
1protein kinase C lambdaIBA
02/2014
1Competitive Endogenous RNAIBA
01/2014
1betaglycan (TGFBR3)IBA
01/2014
1Untranslated RNA (Noncoding RNA)IBA
01/2014

Therapy/Procedure

12Therapeutics
10/2021 - 01/2003
3Drug Therapy (Chemotherapy)
01/2021 - 06/2007
1Immunotherapy
01/2020